5-Amino-1,2,4-thiadiazole → N-[3-chloro-4-(trifluoromethyl)benzyl]-4-[(1,2,4-thiadiazol-5-ylamino)sulfonyl]benzamide

HRID 401736

Reaction equation

HRID 401736 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:19]=[CH:20][C:21]=1[C:22]([F:25])([F:24])[F:23])[CH2:5][NH:6][C:7]([C:9]1[CH:14]=[CH:13][C:12]([S:15](Cl)(=[O:17])=[O:16])=[CH:11][CH:10]=1)=[O:8].[NH2:26][C:27]1[S:31][N:30]=[CH:29][N:28]=1>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:19]=[CH:20][C:21]=1[C:22]([F:25])([F:24])[F:23])[CH2:5][NH:6][C:7](=[O:8])[C:9]1[CH:14]=[CH:13][C:12]([S:15]([NH:26][C:27]2[S:31][N:30]=[CH:29][N:28]=2)(=[O:17])=[O:16])=[CH:11][CH:10]=1

Participants

3

Reactant 2

HCID 2902745-Amino-1,2,4-thiadiazoleHCID 577319284-([[3-Chloro-4-(trifluoromethyl)benzyl]amino]carbonyl)benzenesulfonyl chloride

Product 1

HCID 57732233N-[3-chloro-4-(trifluoromethyl)benzyl]-4-[(1,2,4-thiadiazol-5-ylamino)sulfonyl]benzamideYield 16%

Procedure

The title compound was prepared from 4-({[3-chloro-4-(trifluoromethyl)benzyl]amino}carbonyl)benzenesulfonyl chloride (Preparation 30) and 5-amino-1,2,4-thiadiazole in 16% yield following the Method H described for Example 6.

Sources & evidence

ORD record
ord-e24657fb6f624183b339a7dee92d3196
Source dataset
uspto-grants-2014_06
Patent number
US08741934B2

Linked notes

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