Methylhydrazine → HCID 178498599, compound

Reaction equation

[CH3:1][NH:2][NH2:3].[C:4]([O:12]C)(=O)/[CH:5]=[CH:6]/[C:7]([O:9][CH3:10])=[O:8]>>[OH:12][C:4]1[CH2:5][CH:6]([C:7]([O:9][CH3:10])=[O:8])[N:2]([CH3:1])[N:3]=1

Participants

Reactant 2

HCID 6061Methylhydrazine

HCID 637568Dimethyl Fumarate

Product 1

HCID 178498599HCID 178498599, compound

Procedure

Methyl hydrazine (12 ml, 228 mmol) was added dropwise to dimethyl fumarate (32.8 g, 228 mmol) at −5° C. The mixture was stirred under warming to rt for 16 h and then heated to 100° C. for 3 h. The crude reaction product (36 g, quantitative) was used for the next step without purification. [[M+H]+=159.1]

Workup

temperatureheated to 100° C. for 3 h
customThe crude reaction product (36 g, quantitative)
customwas used for the next step without purification

Sources & evidence

ORD record: ord-ceefb376923e4ee2917ee93895b3fdfa
Source dataset: uspto-grants-2014_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08742106B2

Reaction notes

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