N,N-diethylpiperidin-4-amine dihydrochloride → N,N-diethylpiperidin-4-amine
Reaction equation
Cl.Cl.[CH2:3]([N:5]([CH2:12][CH3:13])[CH:6]1[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1)[CH3:4]>O.[OH-].[Na+]>[CH2:12]([N:5]([CH2:3][CH3:4])[CH:6]1[CH2:7][CH2:8][NH:9][CH2:10][CH2:11]1)[CH3:13]Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
To a solution of 4-(diethylamino)piperidine dihydrochloride (3.0 g, 0.019 mmol) in water (20 mL), 2M sodium hydroxide solution (5.0 mL) was added at ambient temperature. The mixture was stirred for 30 min. The solvent was removed under reduced pressure, and methanol (10 mL) was added to the crude material, then the residue was removed by filtration. The filtrate was concentrated and dried to afford 4-(diethylamino)piperidine (1.7 g, y. 77%) as solid.
Workup
- customThe solvent was removed under reduced pressure, and methanol (10 mL)
- additionwas added to the crude material
- customthe residue was removed by filtration
- concentrationThe filtrate was concentrated
- customdried
Sources & evidence
- ORD record
- ord-e3c7ab6f7b484b4da9c0182a6621a93e
- Source dataset
- uspto-grants-2014_06
- Patent number
- US08742113B2
Reaction notes
Loading…