Ethylacetate heptane → 6-chloro-N-methyl-4-phenylpyridazin-3-amine

HRID 403379

Reaction equation

[Cl:1][C:2]1[N:7]=[N:6][C:5]([NH2:8])=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH:3]=1.[CH3:15]CCCCCC.C(OCC)(=O)C>>[Cl:1][C:2]1[N:7]=[N:6][C:5]([NH:8][CH3:15])=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH:3]=1

Participants

Reactant 2

HCID 21899848Ethylacetate heptane

HCID 768487136-Chloro-4-phenylpyridazin-3-amine

Product 1

HCID 866984786-chloro-N-methyl-4-phenylpyridazin-3-amine

Procedure

The title compound was prepared in analogy to example 1, intermediate a, from 6-chloro-4-phenyl-pyridazin-3-ylamine and using a gradient of n-heptane:ethyl acetate (100:0 to 40:60) for the chromatographic purification. Light yellow solid (52%). MS (ESI+): m/z=220.064 ([M+H]+).

Workup

customfor the chromatographic purification

Sources & evidence

ORD record: ord-7e66c99393e84a34bdda062980d3e56e
Source dataset: uspto-grants-2014_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08748434B2

Linked notes

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