Ethyl 2-thiopheneglyoxylate → HCID 67289955, compound

HRID 403429

Reaction equation

HRID 403429 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH2:10])[C:5]([NH2:9])=[CH:6][C:7]=1[Cl:8].O=[C:12]([C:18]1[S:19][CH:20]=[CH:21][CH:22]=1)[C:13](OCC)=[O:14]>C(O)C>[Cl:1][C:2]1[CH:3]=[C:4]2[C:5](=[CH:6][C:7]=1[Cl:8])[NH:9][C:13](=[O:14])[C:12]([C:18]1[S:19][CH:20]=[CH:21][CH:22]=1)=[N:10]2

Participants

4

Reactant 2

HCID 77693Ethyl 2-thiopheneglyoxylateHCID 792974,5-Dichloro-1,2-phenylenediamine

Product 1

HCID 67289955HCID 67289955, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
70 °C

Procedure

A mixture of 4,5-dichlorobenzene-1,2-diamine (1.0 g, 5.65 mmol), ethyl 2-oxo-2-(thiophen-2-yl)acetate (1.056 g, 5.73 mmol) and ethanol (8 ml) was stirred at 70° C. for 11 h, cooled to room temperature, filtered and washed with cold ethanol. The collected pale yellow solid was dried further (1.07 g) and used directly in next step.

Workup

  1. temperaturecooled to room temperature
  2. filtrationfiltered
  3. washwashed with cold ethanol
  4. customThe collected pale yellow solid was dried further (1.07 g)

Sources & evidence

ORD record
ord-e2e509857fd348abbb23af2cdb1c66cc
Source dataset
uspto-grants-2014_06
Patent number
US08748374B2

Linked notes

Loading…