(S)-2-(6-(4-Benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acid → (S)-2-(6-(4-(3-Fluorobenzamido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acid

HRID 403778

Reaction equation

HRID 403778 reaction equation
C(NC1C=CC(C2C=C3C(CN([C@@H](C(C)C)C(O)=O)C3=O)=CC=2)=CC=1)(=O)C1C=CC=CC=1.[F:33][C:34]1[CH:35]=[C:36]([CH:64]=[CH:65][CH:66]=1)[C:37]([NH:39][C:40]1[CH:45]=[CH:44][C:43]([C:46]2[CH:54]=[C:53]3[C:49]([CH2:50][N:51]([C@@H:56]([CH:61]([CH3:63])[CH3:62])[C:57]([O:59]C)=[O:58])[C:52]3=[O:55])=[CH:48][CH:47]=2)=[CH:42][CH:41]=1)=[O:38]>>[F:33][C:34]1[CH:35]=[C:36]([CH:64]=[CH:65][CH:66]=1)[C:37]([NH:39][C:40]1[CH:45]=[CH:44][C:43]([C:46]2[CH:54]=[C:53]3[C:49]([CH2:50][N:51]([C@@H:56]([CH:61]([CH3:63])[CH3:62])[C:57]([OH:59])=[O:58])[C:52]3=[O:55])=[CH:48][CH:47]=2)=[CH:42][CH:41]=1)=[O:38]

Participants

3

Reactant 2

HCID 53303631(S)-2-(6-(4-Benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acidHCID 123935870(S)-Methyl 2-(6-(4-(3-fluorobenzamido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

Product 1

HCID 67306243(S)-2-(6-(4-(3-Fluorobenzamido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acidYield 84%

Procedure

The compound of example 106 was prepared analogous to compound of example 98 by hydrolysis of compound of example 105.

Sources & evidence

ORD record
ord-2d05a0ef9b75416f9111b03ac6b9b4e7
Source dataset
uspto-grants-2014_06
Patent number
US08748426B2

Linked notes

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