(S)-2-(5-(4-(3-(4-Fluorophenyl)ureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acid → (S)-2-(5-(4-(3-(2-Fluorophenyl)ureido)phenyl)-1-oxoisoindolin-2-yl)-3-methyl butanoic acid
Reaction equation
FC1C=CC(NC(=O)NC2C=CC(C3C=C4C(=CC=3)C(=O)N([C@@H](C(C)C)C(O)=O)C4)=CC=2)=CC=1.[F:35][C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][C:37]=1[NH:42][C:43](=[O:69])[NH:44][C:45]1[CH:50]=[CH:49][C:48]([C:51]2[CH:52]=[C:53]3[C:57](=[CH:58][CH:59]=2)[C:56](=[O:60])[N:55]([C@@H:61]([CH:66]([CH3:68])[CH3:67])[C:62]([O:64]C)=[O:63])[CH2:54]3)=[CH:47][CH:46]=1>>[F:35][C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][C:37]=1[NH:42][C:43](=[O:69])[NH:44][C:45]1[CH:46]=[CH:47][C:48]([C:51]2[CH:52]=[C:53]3[C:57](=[CH:58][CH:59]=2)[C:56](=[O:60])[N:55]([C@@H:61]([CH:66]([CH3:67])[CH3:68])[C:62]([OH:64])=[O:63])[CH2:54]3)=[CH:49][CH:50]=1Participants
3
Reactant 2
Product 1
Procedure
The compound of example 227 was prepared analogous to compound of example 225 by hydrolysis of compound of example 226.