Glycine methyl ester hydrochloride → Methyl 2-(6-bromo-1-oxoisoindolin-2-yl)acetate

Reaction equation

[Br:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][N:7]([C@H:12](C(C)C)[C:13]([O:15][CH3:16])=[O:14])[C:8]2=[O:11])=[CH:4][CH:3]=1.Cl.COC(=O)CN>>[Br:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][N:7]([CH2:12][C:13]([O:15][CH3:16])=[O:14])[C:8]2=[O:11])=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 122755Glycine methyl ester hydrochloride

HCID 131731530(R)-Methyl 2-(6-bromo-1-oxoisoindolin-2-yl)-3-methylbutanoate

Product 1

HCID 67307273Methyl 2-(6-bromo-1-oxoisoindolin-2-yl)acetate

Procedure

The compound of example 332 was prepared analogous to compound of example 329 by reaction of the compound of example 328 and glycine methyl ester hydrochloride.

Sources & evidence

ORD record: ord-a98d817003a24bafaabbcf5931cf6cca
Source dataset: uspto-grants-2014_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08748426B2

Reaction notes

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