Alanine methyl ester hydrochloride → (S)-Methyl 2-(5-bromo-1-oxoisoindolin-2-yl)propanoate

HRID 403960

Reaction equation

HRID 403960 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[C:7](=[O:11])[N:6]([C@H:12]([CH:17](C)C)[C:13]([O:15][CH3:16])=[O:14])[CH2:5]2.BrC1C=CC(C(OC)=O)=C(CBr)C=1.Cl.COC(=O)[C@H](C)N>>[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[C:7](=[O:11])[N:6]([C@@H:12]([CH3:17])[C:13]([O:15][CH3:16])=[O:14])[CH2:5]2

Participants

4

Reactant 3

HCID 2733257Alanine methyl ester hydrochlorideHCID 22031079Methyl 4-bromo-2-(bromomethyl)benzoateHCID 86673568(R)-Methyl 2-(5-bromo-1-oxoisoindolin-2-yl)-3-methylbutanoate

Product 1

HCID 131731537(S)-Methyl 2-(5-bromo-1-oxoisoindolin-2-yl)propanoate

Procedure

The compound of example 365 was prepared analogous to compound of example 359 by reaction of the compound of example 358 and alanine methyl ester hydrochloride.

Sources & evidence

ORD record
ord-b9f5814b6d2345f185e617cff9c4cf2f
Source dataset
uspto-grants-2014_06
Patent number
US08748426B2

Linked notes

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