Methyl 2-amino-2-phenylacetate hydrochloride → Methyl 1-(5-bromo-1-oxoisoindolin-2-yl)cyclopentanecarboxylate

HRID 403966

Reaction equation

HRID 403966 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[C:7](=[O:11])[N:6]([C@H:12]([CH:17]([CH3:19])C)[C:13]([O:15][CH3:16])=[O:14])[CH2:5]2.Br[C:21]1C=CC(C(OC)=O)=C(CBr)[CH:22]=1.Cl.COC(=O)C(C1C=CC=CC=1)N>>[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[C:7](=[O:11])[N:6]([C:12]1([C:13]([O:15][CH3:16])=[O:14])[CH2:17][CH2:19][CH2:22][CH2:21]1)[CH2:5]2

Participants

4

Reactant 3

HCID 12247454Methyl 2-amino-2-phenylacetate hydrochlorideHCID 22031079Methyl 4-bromo-2-(bromomethyl)benzoateHCID 86673568(R)-Methyl 2-(5-bromo-1-oxoisoindolin-2-yl)-3-methylbutanoate

Product 1

HCID 67313405Methyl 1-(5-bromo-1-oxoisoindolin-2-yl)cyclopentanecarboxylate

Procedure

The compound of example 368 was prepared analogous to compound of example 359 by reaction of the compound of example 358 and 2-phenyl glycine methyl ester hydrochloride.

Sources & evidence

ORD record
ord-959043155ce84f1987d11a7d07a798bf
Source dataset
uspto-grants-2014_06
Patent number
US08748426B2

Linked notes

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