beta-Alanine, ethyl ester, hydrochloride → Ethyl 3-(5-bromo-1-oxoisoindolin-2-yl)propanoate

HRID 403972

Reaction equation

HRID 403972 reaction equation
BrC1C=C2C(=CC=1)C(=O)N([C@H](C(C)C)C(OC)=O)C2.[Br:20][C:21]1[CH:30]=[CH:29][C:24]([C:25]([O:27]C)=O)=[C:23]([CH2:31]Br)[CH:22]=1.Cl.[NH2:34][CH2:35][CH2:36][C:37]([O:39][CH2:40][CH3:41])=[O:38]>>[Br:20][C:21]1[CH:22]=[C:23]2[C:24](=[CH:29][CH:30]=1)[C:25](=[O:27])[N:34]([CH2:35][CH2:36][C:37]([O:39][CH2:40][CH3:41])=[O:38])[CH2:31]2

Participants

4

Reactant 3

HCID 458475beta-Alanine, ethyl ester, hydrochlorideHCID 22031079Methyl 4-bromo-2-(bromomethyl)benzoateHCID 86673568(R)-Methyl 2-(5-bromo-1-oxoisoindolin-2-yl)-3-methylbutanoate

Product 1

HCID 67307314Ethyl 3-(5-bromo-1-oxoisoindolin-2-yl)propanoate

Procedure

The compound of example 377 was prepared analogous to compound of example 359 by reaction of the compound of example 358 and ethyl 3-aminopropanoate hydrochloride.

Sources & evidence

ORD record
ord-387a3cef287a4767adf54ab62256bb55
Source dataset
uspto-grants-2014_06
Patent number
US08748426B2

Linked notes

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