Methyl 1-(6-(4-nitrophenyl)-1-oxoisoindolin-2-yl)cyclobutanecarboxylate → Methyl 1-(6-(4-aminophenyl)-1-oxoisoindolin-2-yl)cyclobutanecarboxylate

HRID 404066

Reaction equation

HRID 404066 reaction equation
NC1C=CC(C2C=C3C(CN([C@@H](C(C)C)C(OC)=O)C3=O)=CC=2)=CC=1.[N+:26]([C:29]1[CH:34]=[CH:33][C:32]([C:35]2[CH:43]=[C:42]3[C:38]([CH2:39][N:40]([C:45]4([C:49]([O:51][CH3:52])=[O:50])[CH2:48][CH2:47][CH2:46]4)[C:41]3=[O:44])=[CH:37][CH:36]=2)=[CH:31][CH:30]=1)([O-])=O>>[NH2:26][C:29]1[CH:30]=[CH:31][C:32]([C:35]2[CH:43]=[C:42]3[C:38]([CH2:39][N:40]([C:45]4([C:49]([O:51][CH3:52])=[O:50])[CH2:46][CH2:47][CH2:48]4)[C:41]3=[O:44])=[CH:37][CH:36]=2)=[CH:33][CH:34]=1

Participants

3

Reactant 2

HCID 67313692Methyl 1-(6-(4-nitrophenyl)-1-oxoisoindolin-2-yl)cyclobutanecarboxylateHCID 131731441(S)-Methyl 2-(6-(4-aminophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

Product 1

HCID 67314591Methyl 1-(6-(4-aminophenyl)-1-oxoisoindolin-2-yl)cyclobutanecarboxylateYield 71%

Procedure

The compound of example 574 was prepared analogous to the compound of example 6 by reduction of the compound of example 573.

Sources & evidence

ORD record
ord-69286b2d17094ca7b5f7fc464d2a0cef
Source dataset
uspto-grants-2014_06
Patent number
US08748426B2

Linked notes

Loading…