(S)-2-(6-(4-Benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acid → 1-(6-(4-(4-Chlorobenzamido)phenyl)-1-oxoisoindolin-2-yl)cyclobutane carboxylic acid

HRID 404068

Reaction equation

HRID 404068 reaction equation
C(NC1C=CC(C2C=C3C(CN([C@@H](C(C)C)C(O)=O)C3=O)=CC=2)=CC=1)(=O)C1C=CC=CC=1.[Cl:33][C:34]1[CH:66]=[CH:65][C:37]([C:38]([NH:40][C:41]2[CH:46]=[CH:45][C:44]([C:47]3[CH:55]=[C:54]4[C:50]([CH2:51][N:52]([C:57]5([C:61]([O:63]C)=[O:62])[CH2:60][CH2:59][CH2:58]5)[C:53]4=[O:56])=[CH:49][CH:48]=3)=[CH:43][CH:42]=2)=[O:39])=[CH:36][CH:35]=1>>[Cl:33][C:34]1[CH:66]=[CH:65][C:37]([C:38]([NH:40][C:41]2[CH:46]=[CH:45][C:44]([C:47]3[CH:55]=[C:54]4[C:50]([CH2:51][N:52]([C:57]5([C:61]([OH:63])=[O:62])[CH2:58][CH2:59][CH2:60]5)[C:53]4=[O:56])=[CH:49][CH:48]=3)=[CH:43][CH:42]=2)=[O:39])=[CH:36][CH:35]=1

Participants

3

Reactant 2

HCID 53303631(S)-2-(6-(4-Benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acidHCID 70975309Methyl 1-(6-(4-(4-chlorobenzamido)phenyl)-1-oxoisoindolin-2-yl)cyclobutane carboxylate

Product 1

HCID 673064541-(6-(4-(4-Chlorobenzamido)phenyl)-1-oxoisoindolin-2-yl)cyclobutane carboxylic acidYield 93%

Procedure

The compound of example 578 was prepared analogous to compound of example 98 by hydrolysis of compound of example 577.

Sources & evidence

ORD record
ord-a5bc1844a960473c9c839080e54828ce
Source dataset
uspto-grants-2014_06
Patent number
US08748426B2

Linked notes

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