Methanol → Methyl 3-fluoro-4-hydroxybenzoate
Reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[OH:11])[C:5]([OH:7])=[O:6].S(=O)(=O)(O)O.[CH3:17]O>>[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[OH:11])[C:5]([O:7][CH3:17])=[O:6]Participants
4
Conditions
- Temperature
- 80 °C
Procedure
To a round bottom flask containing 3-fluoro-4-hydroxybenzoic acid (commercially available from Sigma-Aldrich, St. Louis, Mo., USA) (5.03 g, 32.22 mmol) was added a cold solution of MeOH (50.0 mL) and sulfuric acid (2.0 mL). The mixture was heated to 80° C. and monitored with TLC. After 20.5 hours, the solvent was removed and the resulting mixture was diluted with diethyl ether. The organic phase was washed carefully two times with saturated aqueous NaHCO3, once with brine, and then dried over anhydrous sodium sulfate. After filtration, the organic solvent was removed in vacuo to afford T10.1 as a white solid (4.79 g, 87% yield). 1H NMR (400 MHz, CDCl3) 7.81 (2H, m), 7.06 (1H, t, J=8.4 Hz), 5.62 (1H, d, J=4.3 Hz), 3.91 (3H, s).
Workup
- customthe solvent was removed
- additionthe resulting mixture was diluted with diethyl ether
- washThe organic phase was washed carefully two times with saturated aqueous NaHCO3
- dry with materialonce with brine, and then dried over anhydrous sodium sulfate
- filtrationAfter filtration
- customthe organic solvent was removed in vacuo
Sources & evidence
- ORD record
- ord-337ee80103ea4c7fba08271b9b856f9c
- Source dataset
- uspto-grants-2014_06
- Patent number
- US08748462B2
Reaction notes
Loading…