Acetone → 25-Hydroxyvitamin D3

HRID 40441

Reaction equation

HRID 40441 reaction equation
C(O)C.[CH3:4][C@@H:5]([C@@H:13]1[C@@:17]2([CH3:33])[CH2:18][CH2:19][CH2:20]/[C:21](=[CH:22]\[CH:23]=[C:24]3\[CH2:25][C@@H:26]([OH:32])[CH2:27][C@H:28](O)[C:29]\3=[CH2:30])/[C@@H:16]2[CH2:15][CH2:14]1)[CH2:6][CH2:7][CH2:8][C:9]([OH:12])([CH3:11])[CH3:10].CC(C)=O>CS(C)=O>[CH3:4][C@@H:5]([C@@H:13]1[C@@:17]2([CH3:33])[CH2:18][CH2:19][CH2:20]/[C:21](=[CH:22]\[CH:23]=[C:24]3\[CH2:25][C@@H:26]([OH:32])[CH2:27][CH2:28][C:29]\3=[CH2:30])/[C@@H:16]2[CH2:15][CH2:14]1)[CH2:6][CH2:7][CH2:8][C:9]([OH:12])([CH3:10])[CH3:11]

Participants

5

Reactant 3

HCID 180AcetoneHCID 702EthanolHCID 5280453Calcitriol2×

Product 1

HCID 528373125-Hydroxyvitamin D3

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

As a result, as noted in Table 8, ethanol showed a calcitriol production yield of 48.45 mg/L, and acetone and DMSO showed calcitriol production yields of 74.87 mg/L and 70.85 mg/L, respectively, and calcifediol production yields of 156.37 mg/L and 141.81 mg/L, respectively. Especially, methanol showed a calcitriol production yield of 90.12 mg/L, and a calcifediol production yield of 166.87 mg/L.

Workup

  1. customyields of 74.87 mg/L and 70.85 mg/L

Sources & evidence

ORD record
ord-d019f0014c8543afa96d3a977502db42
Source dataset
uspto-grants-2013_09
Patent number
US08530205B2

Linked notes

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