HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 404703Generated: October 23, 2026
Cesium carbonate → 3-(2-Fluoro-4-nitrophenoxy)-2,6-dimethyl-pyridine
https://huagongshe.com/en/reaction/404703
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 2,6-Dimethyl-3-pyridinol | HCID 70732 | — |
| Reactant | 1,2-Difluoro-4-nitrobenzene | HCID 123053 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 3-(2-Fluoro-4-nitrophenoxy)-2,6-dimethyl-pyridine | HCID 59287319 | — |
Reaction Steps
2,6-Dimethyl-pyridin-3-ol (3.0 g, 24.35 mmol) and cesium carbonate (15.87 g, 48.71 mmol) were added to a solution of 3,4-difluoronitrobenzene (3.87 g, 24.35 mmol) in DMF (30 ml). The mixture was heated at 140° C. for 2 hours. After cooling to room temperature it was filtered through diatomaceous earth and the solvent evaporated in vacuo. The crude product was purified by column chromatography (silica gel; 2% methanol/DCM as eluent) to yield intermediate D14 (5.88 g, 92%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08748621B2 |
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| Source dataset | uspto-grants-2014_06 |
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| ORD ID | ord-d4df6e9c113040a08a2f20ae8c1a501d |
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| Source note | uspto-grants-2014_06 |
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