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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 40485Generated: October 26, 2026

Chloromethyl pivalate → 3-[4-(3,3-Dimethyl-2-oxo-5-trifluoromethyl-2,3-dihydroindol-1-ylmethoxy)phenyl]hex-4-ynoic acid

https://huagongshe.com/reaction/40485

Reaction equation

Participants

RoleNameHCIDCharge
ReactantChloromethyl pivalateHCID 87885—
ReactantMethyl 3-(4-hydroxyphenyl)hex-4-ynoateHCID 57835749—
Reactant3,3-Dimethyl-5-(trifluoromethyl)indolin-2-oneHCID 58031719—
Product3-[4-(3,3-Dimethyl-2-oxo-5-trifluoromethyl-2,3-dihydroindol-1-ylmethoxy)phenyl]hex-4-ynoic acidHCID 54766925—

Reaction Steps

Analogously to example 1, 3,3-dimethyl-5-trifluoromethyl-1,3-dihydroindol-2-one, chloromethyl pivalate and methyl 3-(4-hydroxyphenyl)hex-4-ynoate were used to obtain 3-[4-(3,3-dimethyl-2-oxo-5-trifluoromethyl-2,3-dihydroindol-1-ylmethoxy)phenyl]hex-4-ynoic acid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08530413B2
Source datasetuspto-grants-2013_09
ORD IDord-a7437a70bed24e358008440ab46f21fe
Source noteuspto-grants-2013_09