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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 40489Generated: October 26, 2026

Iodomethyl pivalate → 3-[4-(2,2-Dimethyl-3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-ylmethoxy)phenyl]hex-4-ynoic acid

https://huagongshe.com/reaction/40489

Reaction equation

Participants

RoleNameHCIDCharge
ReactantIodomethyl pivalateHCID 104401—
Reactant2,2-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-3-oneHCID 10607395—
ReactantMethyl 3-(4-hydroxyphenyl)hex-4-ynoateHCID 57835749—
Product3-[4-(2,2-Dimethyl-3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-ylmethoxy)phenyl]hex-4-ynoic acidHCID 54767075—

Reaction Steps

Analogously to example 6, 2,2-dimethyl-4H-benzo[1,4]oxazin-3-one, iodomethyl pivalate and methyl 3-(4-hydroxyphenyl)hex-4-ynoate were used to obtain 3-[4-(2,2-dimethyl-3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-ylmethoxy)phenyl]hex-4-ynoic acid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08530413B2
Source datasetuspto-grants-2013_09
ORD IDord-861a1ed39991417e9ddff172b478fe57
Source noteuspto-grants-2013_09