N-((1S)-1-(4-Bromophenyl)ethyl)acetamide → HCID 86689024, compound

HRID 40523Notes

Reaction equation

HRID 40523 reaction equation
[NH:1]1[CH2:4][CH:3]([O:5][C:6]2[CH:11]=[CH:10][C:9]([C:12]([F:15])([F:14])[F:13])=[CH:8][N:7]=2)[CH2:2]1.Br[C:17]1[CH:22]=[CH:21][C:20]([C@@H:23]([NH:25][C:26](=[O:28])[CH3:27])[CH3:24])=[CH:19][CH:18]=1>>[F:13][C:12]([F:15])([F:14])[C:9]1[CH:10]=[CH:11][C:6]([O:5][CH:3]2[CH2:4][N:1]([C:17]3[CH:22]=[CH:21][C:20]([C@@H:23]([NH:25][C:26](=[O:28])[CH3:27])[CH3:24])=[CH:19][CH:18]=3)[CH2:2]2)=[N:7][CH:8]=1

Participants

3

Reactant 2

HCID 793484N-((1S)-1-(4-Bromophenyl)ethyl)acetamideHCID 534087272-(Azetidin-3-yloxy)-5-(trifluoromethyl)pyridine

Product 1

HCID 86689024HCID 86689024, compound

Conditions

Temperature
50 °C

Procedure

Example 8.8 is prepared analogously to 8.1. 2-(Azetidin-3-yloxy)-5-trifluoromethyl-pyridine and (S)—N-[1-(4-bromo-phenyl)-ethyl]-acetamide (I.1) are used as starting materials. Reaction conditions are stirring for 12 h at 50° C.

Workup

  1. customExample 8.8 is prepared analogously to 8.1
  2. customReaction conditions

Sources & evidence

ORD record
ord-50a28f7ae2de4c3ba7ddb1ea6c454f6f
Source dataset
uspto-grants-2013_09
Patent number
US08530461B2

Reaction notes

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