HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 40562Generated: October 26, 2026
Acetonitrile → 5-bromo-N-cyclobutylpyrimidin-2-amine
https://huagongshe.com/reaction/40562
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | Cyclobutylamine | HCID 75645 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 5-Bromo-2-chloropyrimidine | HCID 606665 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 5-bromo-N-cyclobutylpyrimidin-2-amine | HCID 45158687 | — |
Reaction Steps
In a sealed tube 2.00 g (10.3 mmol) 5-bromo-2-chloropyrimidine, 1.15 mL (13.4 mmol) cyclobutylamin and 2.70 mL (15.5 mmol) DIPEA are added to 12 mL ACN. The reaction mixture is stirred at 50° C. over night, then diluted with EtOAc and washed with water (2×). The org. phase is dried with MgSO4 and the solvent is removed in vacuo.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08530460B2 |
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| Source dataset | uspto-grants-2013_09 |
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| ORD ID | ord-2a3a2743c1e9484fb35ba6c301538793 |
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| Source note | uspto-grants-2013_09 |
|---|
