2-Amino-1-(4-chlorophenyl)propan-1-one → HCID 58080354, compound

Reaction equation

[N:1]1(C(OC(C)(C)C)=O)[CH2:6][CH2:5][CH:4]([C:7]([O-:9])=O)[CH2:3][CH2:2]1.[NH2:17][CH:18]([CH3:28])[C:19]([C:21]1[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][CH:22]=1)=O>>[Cl:27][C:24]1[CH:23]=[CH:22][C:21]([C:19]2[O:9][C:7]([CH:4]3[CH2:3][CH2:2][NH:1][CH2:6][CH2:5]3)=[N:17][C:18]=2[CH3:28])=[CH:26][CH:25]=1

Participants

Reactant 2

HCID 2114642-Amino-1-(4-chlorophenyl)propan-1-one

HCID 6921829HCID 6921829, compound

Product 1

HCID 58080354HCID 58080354, compound

Procedure

Starting from mono-tert-butyl piperidine-1,4-dicarboxylate and 2-amino-1-(4-chlorophenyl)-propane-1-one (see J. Med. Chem. 1974, 416) (V-27) may be prepared analogously to (V-26) (see 73.1 and 73.2). Analytical HPLC-MS (method B): RT=1.30 min.

Workup

custommay be prepared analogously to (V-26) (see 73.1 and 73.2)

Sources & evidence

ORD record: ord-dffd512db12e4286825ed3aed6193ad7
Source dataset: uspto-grants-2014_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08754073B2

Reaction notes

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