(3-Benzyloxy-phenoxy)-tert-butyl-dimethyl-silane → 3-(Tert-butyldimethylsilyl)oxy-1-cyclohexanol

HRID 406004Notes

Reaction equation

HRID 406004 reaction equation
C([O:8][C:9]1[CH:10]=[C:11]([CH:20]=[CH:21][CH:22]=1)[O:12][Si:13]([C:16]([CH3:19])([CH3:18])[CH3:17])([CH3:15])[CH3:14])C1C=CC=CC=1>C(O)C>[C:16]([Si:13]([CH3:15])([CH3:14])[O:12][CH:11]1[CH2:20][CH2:21][CH2:22][CH:9]([OH:8])[CH2:10]1)([CH3:19])([CH3:18])[CH3:17]

Participants

3

Reactant 1

HCID 58421755(3-Benzyloxy-phenoxy)-tert-butyl-dimethyl-silane

Product 1

HCID 5570773-(Tert-butyldimethylsilyl)oxy-1-cyclohexanol

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 37.6 g (3-benzyloxy-phenoxy)-tert-butyl-dimethyl-silane and 3.8 g of Nishimura's catalyst in 200 ml of ethanol was hydrogenated at rt under 50 psi for 6 hours. The reaction mixture was filtered and the filtrate concentrated.

Workup

  1. filtrationThe reaction mixture was filtered
  2. concentrationthe filtrate concentrated

Sources & evidence

ORD record
ord-733f331f4f134e8484831a22c5f587cc
Source dataset
uspto-grants-2014_06
Patent number
US08754079B2

Reaction notes

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