3,4-Dimethylbenzaldehyde → 4-(3,4-Dimethyl-benzyl)-piperazine-1-carboxylic acid phenylamide

HRID 40615

Reaction equation

HRID 40615 reaction equation
[C:1]1([NH:7][C:8]([N:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:16][C:17]1[CH:18]=[C:19]([CH:22]=[CH:23][C:24]=1[CH3:25])[CH:20]=O>>[C:1]1([NH:7][C:8]([N:10]2[CH2:15][CH2:14][N:13]([CH2:20][C:19]3[CH:22]=[CH:23][C:24]([CH3:25])=[C:17]([CH3:16])[CH:18]=3)[CH2:12][CH2:11]2)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 222783,4-DimethylbenzaldehydeHCID 7015289N-phenylpiperazine-1-carboxamide

Product 1

HCID 238220274-(3,4-Dimethyl-benzyl)-piperazine-1-carboxylic acid phenylamide

Procedure

The title compound was prepared from piperazine-1-carboxylic acid phenylamide and 3,4-dimethylbenzaldehyde. 1H NMR (400 MHz, CDCl3): 7.35-7.26 (m, 4H), 7.11-7.00 (m, 4H), 6.31 (s, 1H), 3.51-3.48 (m, 6H), 2.49-2.26 (m, 4H), 2.26 (d, J=3.8 Hz, 6H).

Sources & evidence

ORD record
ord-9643308619de4ba7ae14c3db84a9873a
Source dataset
uspto-grants-2013_09
Patent number
US08530476B2

Linked notes

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