Ammonia → 2-Phthalimidoethanesulfonamide

HRID 40757

Reaction equation

HRID 40757 reaction equation
[C:1]1(=[O:17])[N:5]([CH2:6][CH2:7][S:8](Cl)(=[O:10])=[O:9])[C:4](=[O:12])[C:3]2=[CH:13][CH:14]=[CH:15][CH:16]=[C:2]12.[NH3:18]>O1CCOCC1.O>[C:1]1(=[O:17])[N:5]([CH2:6][CH2:7][S:8]([NH2:18])(=[O:10])=[O:9])[C:4](=[O:12])[C:3]2=[CH:13][CH:14]=[CH:15][CH:16]=[C:2]12

Participants

5

Reactant 2

HCID 222AmmoniaHCID 3087392-Phthalimidoethanesulfonyl chloride

Product 1

HCID 960922-Phthalimidoethanesulfonamide

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 312751,4-DioxaneSolvent

Procedure

2-Phthalimidoethanesulfonyl chloride (2.0 g) was added portion wise to a solution of 0.5 M of ammonia in dioxane (15 ml) and the solution obtained this way was stirred at room temperature. After 48 hours the reaction mixture was poured in water (50 ml) causing the title compound to precipitate. The product was collected by filtration. Yield: 1.52 g (83%) of a solid. 1H-NMR (DMSO-δ6) δ (ppm) 7.92-713 (m, 4H), 7.06 (s, 2H), 6.88-3.93 (m, 2H), 3.37-3.30 (m, 2H).

Workup

  1. customthe solution obtained this way

Sources & evidence

ORD record
ord-01d3b421636a46c9afeff37871c6b667
Source dataset
uspto-grants-2013_09
Patent number
US08530486B2

Linked notes

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