(S)-5-dibenzylamino-1-methylpiperidin-2-one → HCID 28064098, compound
Reaction equation
C([N:8](CC1C=CC=CC=1)[C@@H:9]1[CH2:14][N:13]([CH3:15])[C:12](=[O:16])[CH2:11][CH2:10]1)C1C=CC=CC=1>CO.[Pd]>[NH2:8][C@@H:9]1[CH2:14][N:13]([CH3:15])[C:12](=[O:16])[CH2:11][CH2:10]1Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
0.450 g (S)-5-dibenzylamino-1-methylpiperidin-2-one are suspended in 25 ml of methanol and hydrogenated with 0.150 g Pd/C 10% at a pressure of 3 bar and a temperature of 60° C. After 16 hours the catalyst is eliminated by suction filtering and the filtrate is evaporated to dryness. 0.190 g of the product are obtained as an oil. 1H NMR (400 MHz, DMSO): 2.76 (3H, s).
Workup
- customa temperature of 60° C
- filtrationfiltering
- customthe filtrate is evaporated to dryness
Sources & evidence
- ORD record
- ord-73683245091147afbc8d3a467cc93464
- Source dataset
- uspto-grants-2014_06
- Patent number
- US08759326B2
Reaction notes
Loading…