HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 40924Generated: October 26, 2026
Dimethylformamide dimethyl acetal → 1-(3-Cyanophenyl)-3-(dimethylamino)acrolein
https://huagongshe.com/reaction/40924
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide dimethyl acetal | HCID 78373 | — |
| Reactant | 3-Acetylbenzonitrile | HCID 80222 | — |
| Product | 1-(3-Cyanophenyl)-3-(dimethylamino)acrolein | HCID 5714073 | — |
Reaction Steps
3-Acetylbenzonitrile (0.435 g, 0.00300 mol) and 1,1-dimethoxy-N,N-dimethylmethanamine (0.400 mL, 0.00301 mol) were combined and heated in sealed tube to 120° C. in the microwave for 15 min. The reaction was then allowed to cool to rt giving the 3-[(2E)-3-(dimethylamino)prop-2-enoyl]-benzonitrile as a red-orange crystalline material, LC/MS (M+H)+: 201.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08530485B2 |
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| Source dataset | uspto-grants-2013_09 |
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| ORD ID | ord-4ead629fceab4ee8978a94f5b7d08d05 |
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| Source note | uspto-grants-2013_09 |
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