HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cesium carbonate → 2-(4-(1-Methyl-1H-benzo[D]imidazol-2-ylamino)phenoxy)nicotinaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 2-Chloro-3-pyridinecarboxaldehyde | HCID 737607 | — |
| Reactant | 4-(1-methyl-1H-benzoimidazol-2-ylamino)-phenol | HCID 59327014 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 2-(4-(1-Methyl-1H-benzo[D]imidazol-2-ylamino)phenoxy)nicotinaldehyde | HCID 59327252 | — |
Reaction Steps
A solution of 2-chloropyridine-3-carboxaldehyde (3 g, 21 mmol), 4-(1-methyl-1H-benzo[d]imidazol-2-ylamino)phenol (5 g, 21 mmol), CESIUM CARBONATE (10 g, 32 mmol) in DMSO (60 mL) was heated to 80° C. overnight. Purification by aqueous workup (water, brine) and DCM extraction then Biotage (0-10% DCM/MeOH) produced product which partially solidified.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08759532B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-7a1b96e1b00d4beebf739f6685a9bf5c |
| Source note | uspto-grants-2014_06 |