(4-Methylamino-3-nitro-benzoylamino)-acetic acid tert-butyl ester → (4-Methylamino-3-nitro-benzoylamino)-acetic acid

HRID 411051

Reaction equation

HRID 411051 reaction equation
C([O:5][C:6](=[O:22])[CH2:7][NH:8][C:9](=[O:21])[C:10]1[CH:15]=[CH:14][C:13]([NH:16][CH3:17])=[C:12]([N+:18]([O-:20])=[O:19])[CH:11]=1)(C)(C)C>Cl.O1CCOCC1.C(Cl)Cl>[CH3:17][NH:16][C:13]1[CH:14]=[CH:15][C:10]([C:9]([NH:8][CH2:7][C:6]([OH:22])=[O:5])=[O:21])=[CH:11][C:12]=1[N+:18]([O-:20])=[O:19]

Participants

4

Reactant 1

HCID 67332520(4-Methylamino-3-nitro-benzoylamino)-acetic acid tert-butyl ester

Product 1

HCID 67334647(4-Methylamino-3-nitro-benzoylamino)-acetic acidYield 81.4%

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 204431481,4-Dioxane hydrochlorideSolvent

Procedure

(4-Methylamino-3-nitro-benzoylamino)-acetic acid (800 mg) was prepared starting from (4-methylamino-3-nitro-benzoylamino)-acetic acid tert-butyl ester (1.2 g) in 4 M HCl-dioxane (2 mL) and DCM (2 mL). The reaction was stirred at room temperature for 8 h. The solvent was evaporated to isolate pure compound without any further purification.

Workup

  1. customThe solvent was evaporated
  2. customto isolate pure compound
  3. customwithout any further purification

Sources & evidence

ORD record
ord-040cee8d28ca45deb8dd242cb4abb8bb
Source dataset
uspto-grants-2014_06
Patent number
US08759535B2

Linked notes

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