1-(2-Hydroxyethyl)piperazine → 1-Acetyl-4-(2-hydroxyethyl)piperazine

HRID 411156

Reaction equation

HRID 411156 reaction equation
[N:1]1([CH2:7][CH2:8][OH:9])[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[C:10](OC(=O)C)(=[O:12])[CH3:11]>C(Cl)Cl>[OH:9][CH2:8][CH2:7][N:1]1[CH2:6][CH2:5][N:4]([C:10](=[O:12])[CH3:11])[CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 76771-(2-Hydroxyethyl)piperazineHCID 7918Acetic Anhydride

Product 1

HCID 47396291-Acetyl-4-(2-hydroxyethyl)piperazineYield 65%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 2-(1-piperazinyl)-1-ethanol (6.5 g, 0.05 mol) in DCM (5 mL) was treated with acetic acid anhydride (5.1 g, 0.05 mol), added dropwise. During addition, the reaction temperature rose from 22 to 60° C. The reaction mixture was evaporated several times with toluene to yield 5.6 g (65%) of the sub-title compound.

Workup

  1. additionadded dropwise
  2. additionDuring addition
  3. customrose from 22 to 60° C
  4. customThe reaction mixture was evaporated several times with toluene

Sources & evidence

ORD record
ord-0b8309128be54490ac5ad24413da23b1
Source dataset
uspto-grants-2003_05
Patent number
US06559143B1

Linked notes

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