HuagongsheHuagongshe Chemistry Print Report · For research reference only
[Methyl-(toluene-4-sulfonyl)-amino]-acetic acid → N-(toluene-4-sulfonyl)sarcosyl-beta-(3-pyridyl)alanine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | [Methyl-(toluene-4-sulfonyl)-amino]-acetic acid | HCID 802555 | — |
| Reactant | H-Ala(3-pyridyl)-OMe.2HCl | HCID 46862166 | — |
| Product | N-(toluene-4-sulfonyl)sarcosyl-beta-(3-pyridyl)alanine | HCID 20582824 | 17% |
Reaction Steps
N-(Toluene-4-sulfonyl)sarcosine was coupled to 3-(3-pyridyl)alanine methyl ester dihydrochloride using the procedure described in Method 3 to give N-(toluene4-sulfonyl)sarcosyl-β-(3-pyridyl)alanine (166 mg, 17%). The title compound was prepared via hydrolysis of the methyl ester using 1N aqueous NaOH in dioxane/water (129 mg, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06559127B1 |
| Source dataset | uspto-grants-2003_05 |
| ORD ID | ord-457e9e75b68c4e00b1419dcb7856c339 |
| Source note | uspto-grants-2003_05 |