Acetic Anhydride → 1-Acetyl-7-methylindoline

HRID 411279

Reaction equation

HRID 411279 reaction equation
[CH3:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[NH:9][CH2:8][CH2:7]2.[C:11](OC(=O)C)(=[O:13])[CH3:12]>>[C:11]([N:9]1[C:10]2[C:6](=[CH:5][CH:4]=[CH:3][C:2]=2[CH3:1])[CH2:7][CH2:8]1)(=[O:13])[CH3:12]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 123777887-Methyl-2,3-dihydro-1H-indole

Product 1

HCID 143613661-Acetyl-7-methylindoline

Procedure

A solution of 7-methylindoline (10.2 g) in acetic anhydride (25 ml) was refluxed for 30 min. After cooling, the reaction solution was poured into ice water (250 ml) and the resulting crystal was filtered by means of suction, heated and vacuum dried to yield the end product (11.7 g).

Workup

  1. temperatureAfter cooling
  2. filtrationthe resulting crystal was filtered by means of suction
  3. temperatureheated
  4. customvacuum dried

Sources & evidence

ORD record
ord-532146205184410b96c1b186bb23c4a5
Source dataset
uspto-grants-2003_05
Patent number
US06559149B1

Linked notes

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