Sodium Cyanide → (4R,5R)-5-(4-Methoxy-3-methyl-phenyl)-4-(toluene-4-sulfonyl)-4,5-dihydro-oxazole

Participants

Role	Name	HCID	Charge
Reactant	Sodium Cyanide	HCID 8929	—
Reactant	3-Methyl-4-anisaldehyde	HCID 122936	—
Reactant	Tosylmethyl isocyanide	HCID 161915	—
Product	(4R,5R)-5-(4-Methoxy-3-methyl-phenyl)-4-(toluene-4-sulfonyl)-4,5-dihydro-oxazole	HCID 12116615	—

Reaction Steps

In a manner analogous to Preparation 1, 3-methyl-p-anisaldehyde (0.73 mL, 5.25 mmol), tosylmethylisocyanide (0.98 g, 5.00 mmol) and NaCN (24.5 mg, 0.50 mmol) gave the desired compound as a tan solid. MS(ES+) m/z 346.7 (M+H+).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06559172B1
Source dataset	uspto-grants-2003_05
ORD ID	ord-feb727ce94074a1ea9c3649ed903b350
Source note	uspto-grants-2003_05