2-Ethoxybenzoyl chloride → 2-(2-Ethoxybenzamido)-3-methylbenzamide

Reaction equation

[NH2:1][C:2]1[C:10]([CH3:11])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5].[CH2:12]([O:14][C:15]1[CH:23]=[CH:22][CH:21]=[CH:20][C:16]=1[C:17](Cl)=[O:18])[CH3:13]>>[CH2:12]([O:14][C:15]1[CH:23]=[CH:22][CH:21]=[CH:20][C:16]=1[C:17]([NH:1][C:2]1[C:10]([CH3:11])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5])=[O:18])[CH3:13]

Participants

Reactant 2

HCID 30163972-Ethoxybenzoyl chloride

HCID 142218072-Amino-3-methylbenzamide

Product 1

HCID 185365992-(2-Ethoxybenzamido)-3-methylbenzamide

Procedure

The title compound was prepared from 2-amino-3-methylbenzamide (Chem. Pharm. Bull., 1988, 36, 2955) and 2-ethoxybenzoyl chloride following the procedure of Preparation 5 and was obtained as colourless crystals (71%), m.p. 197-200° C.

Workup

customthe procedure of Preparation 5

Sources & evidence

ORD record: ord-ca8550a7f4c8409fb25406d710a9893b
Source dataset: uspto-grants-2003_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06562830B1

Reaction notes

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