Water → Laurolactam

Reaction equation

[C:1]1(=[N:13]O)[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[OH2:15]>>[C:1]1(=[O:15])[NH:13][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12]1

Participants

Reactant 2

HCID 962Water

HCID 136762Cyclododecanone, oxime

Product 1

HCID 13690Laurolactam

Procedure

For example, after the reaction of cyclododecanone oxime, the reaction can be worked up by adding water, extracting a product with an organic solvent and then evaporating the solvent to give laurolactam, which can be further separated and purified by, for example, distillation or crystallization.

Workup

customthe reaction
extractionextracting a product with an organic solvent
customevaporating the solvent

Sources & evidence

ORD record: ord-bf9970b51c7248ce8751f7ff38820cf3
Source dataset: uspto-grants-2013_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08530645B2

Reaction notes

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