HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosgene → 10-Methoxy-5H-dibenz(b,f)azepine-5-carbonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosgene | HCID 6371 | — |
| Reactant | Oxcarbazepine | HCID 34312 | — |
| Reactant | 10-Methoxyiminostilbene | HCID 78424 | — |
| Product | 10-Methoxy-5H-dibenz(b,f)azepine-5-carbonyl chloride | HCID 16050081 | — |
Reaction Steps
U.S. Pat. No. 3,642,775 assigned to Ciba-Geigy Corporation, claims Oxcarbazepine specifically and discloses the process for the preparation of Oxcarbazepine, wherein 10-methoxy-5H-dibenz[b,f]azepine is reacted with phosgene gas to give 10-methoxy-5H-dibenz[b,f]azepine-5-carbonyl chloride and ammonolysis of the resultant compound to give the amide followed by hydrolysis to give Oxcarbazepine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08530647B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-60bf5f9e5dc041ce8cc30181f4c613f9 |
| Source note | uspto-grants-2013_09 |