(R)-Tetrahydro-3-furoic acid → 5-{N'-(tetrahydro-3-furoyl)-L-alaninyl}-amino-7-methyl-5,7-dihydro-6H-dibenz[b,d]azepin-6-one

HRID 413852

Reaction equation

HRID 413852 reaction equation
[O:1]1[CH2:5][CH2:4][CH:3]([C:6]([OH:8])=O)[CH2:2]1.[NH2:9][C@H:10]([C:12]([N:14]1[C:20](=[O:21])[CH:19]([CH3:22])[C:18]2[CH:23]=[CH:24][CH:25]=[CH:26][C:17]=2[C:16]2[C:27]([NH2:31])=[CH:28][CH:29]=[CH:30][C:15]1=2)=[O:13])[CH3:11]>>[O:1]1[CH2:5][CH2:4][CH:3]([C:6]([NH:9][C@H:10]([C:12]([N:14]2[C:20](=[O:21])[CH:19]([CH3:22])[C:18]3[CH:23]=[CH:24][CH:25]=[CH:26][C:17]=3[C:16]3[C:27]([NH2:31])=[CH:28][CH:29]=[CH:30][C:15]2=3)=[O:13])[CH3:11])=[O:8])[CH2:2]1

Participants

3

Reactant 2

HCID 4661317(R)-Tetrahydro-3-furoic acidHCID 697363355-(L-alaninyl)-amino-7-methyl-5,7-dihydro-6H-dibenz[b,d]azepin-6-one

Product 1

HCID 865925885-{N'-(tetrahydro-3-furoyl)-L-alaninyl}-amino-7-methyl-5,7-dihydro-6H-dibenz[b,d]azepin-6-one

Procedure

Following General Procedure C-P above using tetrahydro-3-furoic acid and 5-(L-alaninyl)-amino-7-methyl-5,7-dihydro-6H-dibenz[b,d]azepin-6-one, as described in Example 7-B, the title compound was prepared. The molecular weight as determined by mass spectrometry (FD) was: 408 (M+H).

Sources & evidence

ORD record
ord-6e67a3aad5794b41bd1ab7793f7ad298
Source dataset
uspto-grants-2003_05
Patent number
US06569851B1

Linked notes

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