2-Hydroxyisobutyric acid → 5-{N'-(2-hydroxy-2-methylpropionyl)-L-alaninyl}-amino-7-methyl-5,7-dihydro-6H-dibenz[b,d]azepin-6one

HRID 413863

Reaction equation

HRID 413863 reaction equation
[CH3:1][C:2]([CH3:7])([OH:6])[C:3](O)=[O:4].[NH2:8][C@H:9]([C:11]([N:13]1[C:19](=[O:20])[CH:18]([CH3:21])[C:17]2[CH:22]=[CH:23][CH:24]=[CH:25][C:16]=2[C:15]2[C:26]([NH2:30])=[CH:27][CH:28]=[CH:29][C:14]1=2)=[O:12])[CH3:10]>>[OH:6][C:2]([CH3:7])([CH3:1])[C:3]([NH:8][C@H:9]([C:11]([N:13]1[C:19](=[O:20])[CH:18]([CH3:21])[C:17]2[CH:22]=[CH:23][CH:24]=[CH:25][C:16]=2[C:15]2[C:26]([NH2:30])=[CH:27][CH:28]=[CH:29][C:14]1=2)=[O:12])[CH3:10])=[O:4]

Participants

3

Reactant 2

HCID 116712-Hydroxyisobutyric acidHCID 697363355-(L-alaninyl)-amino-7-methyl-5,7-dihydro-6H-dibenz[b,d]azepin-6-one

Product 1

HCID 865925965-{N'-(2-hydroxy-2-methylpropionyl)-L-alaninyl}-amino-7-methyl-5,7-dihydro-6H-dibenz[b,d]azepin-6one

Procedure

Following General procedure D above using 2-methyllactic acid (Aldrich) and 5-(L-alaninyl)-amino-7-methyl-5,7-dihydro-6H-dibenz[b,d]azepin-6-one, as described in Example 7-B, the title compound was prepared. The product was purified by flash chromatography CHCl3/MeOH (98:2) to yield the title compound.

Workup

  1. customthe title compound was prepared
  2. customThe product was purified by flash chromatography CHCl3/MeOH (98:2)

Sources & evidence

ORD record
ord-db54aeac54a7496484d7b33f7ef7e03f
Source dataset
uspto-grants-2003_05
Patent number
US06569851B1

Linked notes

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