2-Isocyanatothiophene → (N'-((2-(2-Thiophene-yl)ethyl)aminocarbonyl)-L-alaninyl)amino-2,3-dihydro-1-methyl-5-phenyl-1H-1,4-benzodiazepin-2-one

HRID 413869

Reaction equation

HRID 413869 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1N=C=O.[NH2:9][C@H:10]([C:12]([NH:14][CH:15]1[N:21]=[C:20]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[C:19]2[CH:28]=[CH:29][CH:30]=[CH:31][C:18]=2[N:17]([CH3:32])[C:16]1=[O:33])=[O:13])[CH3:11]>>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:16][CH2:15][NH:14][C:12]([NH:9][C@H:10]([C:12]([NH:14][CH:15]1[N:21]=[C:20]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[C:19]2[CH:28]=[CH:29][CH:30]=[CH:31][C:18]=2[N:17]([CH3:32])[C:16]1=[O:33])=[O:13])[CH3:11])=[O:13]

Participants

3

Reactant 2

HCID 27763752-IsocyanatothiopheneHCID 235527623-(L-alaninyl)amino-2,3-dihydro-1-methyl-5-phenyl-1H-1,4-benzodiazepin-2-one

Product 1

HCID 86758990(N'-((2-(2-Thiophene-yl)ethyl)aminocarbonyl)-L-alaninyl)amino-2,3-dihydro-1-methyl-5-phenyl-1H-1,4-benzodiazepin-2-one

Procedure

Following General Procedure (5-A1) using 2-thiophene-yl isocyanate and 3-[(L-alaninyl)]amino-2,3-dihydro-1-methyl-5-phenyl-1H-1,4-benzodiazepin-2-one, as described in Example 8-B above, the title compound was prepared. The molecular weight as determined by mass spectrometry (FD) was: (M+H).

Sources & evidence

ORD record
ord-27f66d695ede4faa98323d6d95b1e560
Source dataset
uspto-grants-2003_05
Patent number
US06569851B1

Linked notes

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