HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluenesulfonic acid → 1-(3-Acetylphenyl)-2-methyl-5-phenyl-1H-pyrrole-3-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | 3'-Aminoacetophenone | HCID 7417 | — |
| Reactant | Ethyl 2-acetyl-4-oxo-4-phenylbutanoate | HCID 312893 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-(3-Acetylphenyl)-2-methyl-5-phenyl-1H-pyrrole-3-carboxylic acid ethyl ester | HCID 10291357 | — |
Reaction Steps
3′-Aminoacetophenone (5 mmol, 0.7 g), 3-oxo-2-(2-oxo-2-phenyl-ethyl)-butyric acid ethyl ester (5 mmol, 1.2 g), and tosic acid (0.1 g) were combined in ethanol, then heated under reflux. The resulting oil was purified over silica and yielded the named product as a solid (m.p. 102° C.-104° C.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06569890B2 |
| Source dataset | uspto-grants-2003_05 |
| ORD ID | ord-e387fed91b954fe78ef985136441d255 |
| Source note | uspto-grants-2003_05 |