HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,2,4-Trimethylpentane → 3,5-dichloro-N-[(1-ethylpyrrolidin-2-yl)methyl]-2-hydroxy-6-methoxybenzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,2,4-Trimethylpentane | HCID 10907 | — |
| Reactant | Benzamide, 3,5-dichloro-2,6-dimethoxy-N-(1-ethyl-2-pyrrolidinylmethyl)- | HCID 54941 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 3,5-dichloro-N-[(1-ethylpyrrolidin-2-yl)methyl]-2-hydroxy-6-methoxybenzamide | HCID 5118 | 37% |
Reaction Steps
The title compound was prepared from (-)-N-ethyl-2-(3,5-dichloro-2,6-dimethoxybenzamidomethyl)pyrrolidine by dealkylation in the same manner as described in Example 2. Yield 37%. M.p. 48°-49° C. (i-octane). [α]D25 =-64° C. (c=1.26; CHCl3).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04789683 |
| Source dataset | uspto-grants-1988_12 |
| ORD ID | ord-611965bfa22442ada288636db728707e |
| Source note | uspto-grants-1988_12 |