Phenylhydrazine hydrochloride → 1-(2-Methyl-4-aminopyrimidyl)methylidene-2-phenylhydrazine hydrochloride

HRID 414767

Reaction equation

HRID 414767 reaction equation
[CH3:1][C:2]1[N:7]=[C:6]([NH2:8])[C:5]([CH:9]=O)=[CH:4][N:3]=1.[ClH:11].[C:12]1([NH:18][NH2:19])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>CO>[ClH:11].[CH3:1][C:2]1[N:7]=[C:6]([NH2:8])[C:5]([CH:9]=[N:19][NH:18][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[CH:4][N:3]=1

Participants

4

Reactant 2

HCID 60962Phenylhydrazine hydrochlorideHCID 129047264-Amino-2-methylpyrimidine-5-carbaldehyde

Product 1

HCID 704196431-(2-Methyl-4-aminopyrimidyl)methylidene-2-phenylhydrazine hydrochlorideYield 99.8%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In 333 ml of methanol was dissolved 8.6 g of 2-methyl-4-amino-5-formylpyrimidine. To the solution was added gradually 10.6 g of phenyl hydrazine hydrochloride. As the reaction proceeded, crystals precipitated out. Five hours later, the crystals were collected by filtration and dried under reduced pressure to obtain 16.5 g (93%) of 1-(2-methyl-4-aminopyrimidyl)methylidene-2-phenylhydrazine hydrochloride. Physical properties of 1-(2-methyl-4-aminopyrimidyl)methylidene-2-phenylhydrazine hydrochloride are as follows:

Workup

  1. customcrystals precipitated out
  2. filtrationFive hours later, the crystals were collected by filtration
  3. customdried under reduced pressure

Sources & evidence

ORD record
ord-837e8fc9dc2a4cf58e596f243f4f152e
Source dataset
uspto-grants-1988_12
Patent number
US04794182

Linked notes

Loading…