HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Toluenesulfonyl chloride → 1-(4-Methylbenzene-1-sulfonyl)-1H-indole-3-carbaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Toluenesulfonyl chloride | HCID 7397 | — |
| Reactant | 1,2-Dimethoxyethane | HCID 8071 | — |
| Reactant | Indole-3-Carboxaldehyde | HCID 10256 | — |
| Product | 1-(4-Methylbenzene-1-sulfonyl)-1H-indole-3-carbaldehyde | HCID 735817 | — |
Reaction Steps
To a solution of indole-3-carbaldehyde (4.0 g, 27.586 mmol) in 1,2-dimethoxyethane (40 mL) KOH (4.63 g, 82.758 mmol) was added at rt and stirred for 10 min. p-toluene sulfonyl chloride (5.785 g, 30.345 mmol) was added to the solution at rt and stirred for 18 h.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08530648B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-dc9571d6796a4b6cbea573bdf16c0c9f |
| Source note | uspto-grants-2013_09 |