2,4,5,6-Tetrachloropyrimidine → HCID 178493073, compound

HRID 415441

Reaction equation

HRID 415441 reaction equation
[Cl:1][C:2]1[N:7]=[C:6]([Cl:8])[C:5]([Cl:9])=[C:4](Cl)[N:3]=1.Cl.[CH3:12][O:13][C:14]1[NH:18][N:17]=[C:16]([NH2:19])[CH:15]=1>C(O)C>[Cl:1][C:2]1[N:3]=[C:4]([NH:19][C:16]2[CH:15]=[C:14]([O:13][CH3:12])[NH:18][N:17]=2)[C:5]([Cl:9])=[C:6]([Cl:8])[N:7]=1

Participants

4

Reactant 2

HCID 156902,4,5,6-TetrachloropyrimidineHCID 178493289HCID 178493289, compound

Product 1

HCID 178493073HCID 178493073, compoundYield 25.8%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 2,4,5,6-tetrachloro-pyrimidine (2.18 g) in absolute ethanol (100 mL) was added DIEPA (4.4 mL) and 5-methoxy-1H-pyrazol-3-amine hydrogen chloride salt (1.50 g). The resulting solution was stirred at room temperature for over night. The solvent was evaporated under reduced pressure. The crude compound was purified by Gilson (10-60% MeCN/H2O, 15 minutes) to give the titled compound as solid (0.76 g). m/z 294.

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. customThe crude compound was purified by Gilson (10-60% MeCN/H2O, 15 minutes)

Sources & evidence

ORD record
ord-31b3bb9ac5eb443390e029345ae3ca5f
Source dataset
uspto-grants-2012_01
Patent number
US08088784B2

Linked notes

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