(2R)-propane-1,2-diamine dihydrochloride → HCID 136174526, compound

Reaction equation

[CH3:1][C@H:2]1[N:6]2[C:7]3[C:16]4[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=4)[N:10]=[CH:9][C:8]=3[N:17]=[C:5]2[NH:4][CH2:3]1.Cl.Cl.[NH2:20]C[C@H](N)C.Cl.Cl.NC[C@@H](N)C>>[CH3:1][C@H:2]1[N:6]2[C:7]3[C:16]4[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=4)[N:10]=[C:9]([NH2:20])[C:8]=3[N:17]=[C:5]2[NH:4][CH2:3]1

Participants

Reactant 3

HCID 12217444(2R)-propane-1,2-diamine dihydrochloride

HCID 12217445(2S)-Propane-1,2-diamine--hydrogen chloride (1/2)

HCID 136356809HCID 136356809, compound2×

Product 1

HCID 136174526HCID 136174526, compound

Procedure

The methods described in Parts A through C of Example 23 were used to prepare (10R)-10-methyl-9,10-dihydro-8H-imidazo[1′,2′:1,2]imidazo[4,5-c]quinoline with (R)-(−)-1,2-diaminopropane dihydrochloride used in lieu of (S)-(−)-1,2-diaminopropane dihydrochloride in Part A. The methods described in Parts A through D of Example 27 were used to convert (10R)-10-methyl-9,10-dihydro-8H-imidazo[1′,2′:1,2]imidazo[4,5-c]quinoline to the title compound, which was obtained as a white solid, m.p. 272-274° C.