1-Bromo-4-(trifluoromethoxy)benzene → 1-(5-(4-(Trifluoromethoxy)phenyl)thien-2-yl)ethanone

HRID 416036

Reaction equation

HRID 416036 reaction equation
[C:1]([C:4]1[S:8][C:7](B(O)O)=[CH:6][CH:5]=1)(=[O:3])[CH3:2].Br[C:13]1[CH:18]=[CH:17][C:16]([O:19][C:20]([F:23])([F:22])[F:21])=[CH:15][CH:14]=1>>[F:21][C:20]([F:22])([F:23])[O:19][C:16]1[CH:17]=[CH:18][C:13]([C:7]2[S:8][C:4]([C:1](=[O:3])[CH3:2])=[CH:5][CH:6]=2)=[CH:14][CH:15]=1

Participants

3

Reactant 2

HCID 5210081-Bromo-4-(trifluoromethoxy)benzeneHCID 4143377(5-Acetylthiophen-2-yl)boronic acid

Product 1

HCID 591803511-(5-(4-(Trifluoromethoxy)phenyl)thien-2-yl)ethanone

Procedure

1-(5-(4-(Trifluoromethoxy)phenyl)thien-2-yl)ethanone is prepared from 5-acetyl-2-thiopheneboronic acid and 1-bromo-4-(trifluoromethoxy)benzene according to general procedure A.

Sources & evidence

ORD record
ord-f2bdb42370b145aa8fc331e1d5ce3b3a
Source dataset
uspto-grants-2012_01
Patent number
US08088819B2

Linked notes

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