HCID 22266530, compound → 1-butyl-3-hydroxy-4(N,N-dimethylaminomethyl)pyridine-2-thione
Reaction equation
[CH2:1]([N:5]1[CH:10]=[CH:9][CH:8]=[C:7]([OH:11])[C:6]1=[S:12])[CH2:2][CH2:3][CH3:4]>C(O)C>[CH2:1]([N:5]1[CH:10]=[CH:9][C:8]([CH2:1][N:5]([CH3:10])[CH3:6])=[C:7]([OH:11])[C:6]1=[S:12])[CH2:2][CH2:3][CH3:4]Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 75 °C
Procedure
To a solution of 1-butyl-3-hydroxypyridine-2-thione (2-034-04) (1.0 g) in ethanol containing 10% water (20 mL) was added N, N, N′, N′-teteramethyldiaminomethane (1.70 g) at room temperature. After the reaction mixture was stirred at 75° C. for 24 h, the solvent was evaporated under reduced pressure to give 1-butyl-3-hydroxy-4(N,N-dimethylaminomethyl)pyridine-2-thione (2-034-05) (1.3 g, 95%) as an oil.
Workup
- customthe solvent was evaporated under reduced pressure
Sources & evidence
- ORD record
- ord-d192df92636240e1a22cd6a213a9c0d9
- Source dataset
- uspto-grants-2012_01
- Patent number
- US08088924B2
Reaction notes
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