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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 41732Generated: October 26, 2026

4-Hydroxybenzaldehyde → 4-((2-Fluorophenyl)methoxy)benzaldehyde

https://huagongshe.com/reaction/41732

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-HydroxybenzaldehydeHCID 126—
ReactantBenzene, 1-(chloromethyl)-2-fluoro-HCID 9580—
Product4-((2-Fluorophenyl)methoxy)benzaldehydeHCID 702717—

Reaction Steps

4-(2-Fluorobenzyloxy)benzaldehyde is prepared by alkylation of 4-hydroxybenzaldehyde (0.39 g) with 2-fluorobenzyl chloride by following the same procedure of Example 1, but using three different phase transfer catalysts.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08530701B2
Source datasetuspto-grants-2013_09
ORD IDord-98f7225d9ac847d8aeb49aa56a0d9395
Source noteuspto-grants-2013_09