HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 4177Generated: October 26, 2026
(Chlorothio)formyl chloride → 5-[2-(4-Hydroxy-3,5-di-tert-butylphenyl)ethyl]-1,3,4-oxathiazol-2-one
https://huagongshe.com/reaction/4177
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | (Chlorothio)formyl chloride | HCID 75990 | — |
| Reactant | 3-(3,5-Di-tert-butyl-4-hydroxyphenyl)propanamide | HCID 12271476 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 5-[2-(4-Hydroxy-3,5-di-tert-butylphenyl)ethyl]-1,3,4-oxathiazol-2-one | HCID 20152932 | — |
Reaction Steps
A suspension of 13.45 grams of 3-[4-hydroxy-3,5-di- tert-butylphenyl]propionamide in 150 ml of toluene is admixed with 20.22 grams of chlorocarbonyl sulfenyl chloride added dropwise. After heating the reaction mixture at 60° C. for 20 hours, the solvent is removed under reduced pressure. The residue is recrystallized from heptane to give the title compound as a pale yellow crystalline solid: mp 82°-86° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04724246 |
|---|
| Source dataset | uspto-grants-1988_02 |
|---|
| ORD ID | ord-aceb139e08c74474b4660ef26669537f |
|---|
| Source note | uspto-grants-1988_02 |
|---|
