3-Fluoro-4-(2-(1-methyl-1H-imidazol-2-yl)thieno[3,2-b]pyridin-7-yloxy)benzenamine → 3-Fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)benzenamine

HRID 418573Notes

Reaction equation

HRID 418573 reaction equation
FC1C=C(N)C=CC=1OC1C=CN=C2C=C(C3N(C)C=CN=3)SC=12.[F:25][C:26]1[CH:47]=[C:46]([N+:48]([O-])=O)[CH:45]=[CH:44][C:27]=1[O:28][C:29]1[CH:34]=[CH:33][N:32]=[C:31]2[CH:35]=[C:36]([C:38]3[N:39]=[CH:40][N:41]([CH3:43])[CH:42]=3)[S:37][C:30]=12>>[F:25][C:26]1[CH:47]=[C:46]([NH2:48])[CH:45]=[CH:44][C:27]=1[O:28][C:29]1[CH:34]=[CH:33][N:32]=[C:31]2[CH:35]=[C:36]([C:38]3[N:39]=[CH:40][N:41]([CH3:43])[CH:42]=3)[S:37][C:30]=12

Participants

3

Reactant 2

HCID 594244803-Fluoro-4-(2-(1-methyl-1H-imidazol-2-yl)thieno[3,2-b]pyridin-7-yloxy)benzenamineHCID 594245127-(2-Fluoro-4-nitrophenoxy)-2-(1-methyl-1H-imidazol-4-yl)thieno[3,2-b]pyridine

Product 1

HCID 594245073-Fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)benzenamine

Procedure

Following the procedure described for the amine 9 (example 2, step 5) but substituting nitro-compound 8 for compound 11, title compound 12 was obtained as a red solid (82% yield). MS (m/z): 341.1 (M+H).

Sources & evidence

ORD record
ord-27e6a5e742f64160ac1e16accea5bd0f
Source dataset
uspto-grants-2012_01
Patent number
US08093264B2

Reaction notes

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