1h-Indazole,4-bromo-1-(2-fluorophenyl)-6-methyl- → 1h-Indazole,4-bromo-6-methyl-1-phenyl-

Reaction equation

[Br:1][C:2]1[CH:10]=[C:9]([CH3:11])[CH:8]=[C:7]2[C:3]=1[CH:4]=[N:5][N:6]2[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1F.C1(NN=CC2C(Br)=CC(C)=CC=2Br)C=CC=CC=1>>[Br:1][C:2]1[CH:10]=[C:9]([CH3:11])[CH:8]=[C:7]2[C:3]=1[CH:4]=[N:5][N:6]2[C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1

Participants

Reactant 2

HCID 576159291h-Indazole,4-bromo-1-(2-fluorophenyl)-6-methyl-

HCID 666483122,6-Dibromo-4-methylbenzaldehyde phenylhydrazone2×

Product 1

HCID 576159611h-Indazole,4-bromo-6-methyl-1-phenyl-

Procedure

Similarly prepared to Intermediate 26 from 2,6-dibromo-4-methylbenzaldehyde phenylhydrazone (Intermediate 32).

Sources & evidence

ORD record: ord-2f5c5eab6ad440deacf29542f6e304bd
Source dataset: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08093281B2

Reaction notes

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